RING1BGoat anti-Bovine, Canine, Chicken, Chimpanzee, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-194-3825-Each-of-1 | In Stock | ₹ 52,930.08 |
50-194-3825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,930.08
GST (18%): ₹ 9,527.414
Total Price: ₹ 62,457.494
Antigen
RING1B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RNF2
Gene Alias
AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; BOS_16138; DING; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; Protein DinG; RING 1B; RING 2; RING finger protein 1B; RING finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; RNF2; wu:fa19h05; wz4556; wz4566
Host Species
Goat
Regulatory Status
RUO
Gene ID (Entrez)
19821, 304850, 424452, 457581, 480042, 540090, 6045
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Concentration
1.1 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
Q4KLY4, Q99496, Q9CQJ4
Gene Symbols
RNF2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Canine, Chicken, Chimpanzee, Human, Mouse, Non-human Primate, Rat, X. laevis
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- Affinity purified Anti-RING1B antibody is directed against human RING1B protein
- A BLAST analysis was used to suggest reactivity with this protein from human, chimpanzee, orangutan, mouse, rat, dog, bovine, frog and chicken based on 100% homology for the immunogen sequence
- Expect cross reactivity with RING1B from zebrafish, as only a single amino acid residue changes within the immunogen sequence (92% positive by BLAST)
- Cross reactivity with RING1B homologues from other sources has not been determined
- RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub)
- Therefore, it plays a central role in histone code and gene regulation
- The ligase activity is enhanced by BMI1/PCGF4
- H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals
- RNF2 may be involved in the initiation of both imprinted and random X inactivation
- RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex
- This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development
- The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.