CD28 Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-2514-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-2514 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
CD28
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cd28
Gene Alias
antigen CD28; BOS_1949; CD28; CD28 antigen; CD28 antigen (Tp44); Cd28 molecule; CD28 precursor protein; CD28RNA; cell surface protein; CHT28; costimulatory molecule B7 receptor CD28; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
940
Content And Storage
-20°C
Form
Liquid
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
P10747
Gene Symbols
Cd28
Immunogen
KLH conjugated synthetic peptide derived from mouse CD28.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein
- CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes
- Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells
- In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death
- In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28
- In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR
- The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells
- Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary′s Disease.