50-198-2817
TFAR19/PDCD5 Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-2817-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-2817 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
TFAR19/PDCD5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDCD5
Gene Alias
2200003D22Rik; AA408513; Pdcd5; programmed cell death 5; Programmed cell death protein 5; Protein TFAR19; TF1 cell apoptosis-related gene 19; TF-1 cell apoptosis-related protein 19; Tfar19; TFAR19 novel apoptosis-related
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
9141
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
O14737
Gene Symbols
PDCD5
Immunogen
KLH conjugated synthetic peptide derived from human TFAR19.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis
- PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus
- PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region
- The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein
- PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death
- PDCD5 may play a dual role in the Tip60 pathway
- It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis
- The nucleotide polymorphisms in the 5′-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.