GOLPH3 Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-2909-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-2909 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
GOLPH3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Golph3
Gene Alias
4733401N08Rik; 5730410D03Rik; AW413496; Coat protein GPP34; coat-protein; Gmx33; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi phosphoprotein 3 (coat-protein); golgi protein; golgi-associated protein; GOLPH3; GOPP1; Gpp34; MIDAS; Mitochondrial DNA absence factor; trans-Golgi protein GMx33; Vps74
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
64083
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q9H4A6
Gene Symbols
Golph3
Immunogen
KLH conjugated synthetic peptide derived from human GOLPH3.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin
- GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway
- Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro
- Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF
- Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes
- These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.