50-198-5118
Phospho-CD19 (Tyr531) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5118-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5118 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-CD19 (Tyr531)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cd19
Gene Alias
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CD19; CD19 antigen; CD19 molecule; CVID3; Differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
930
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
P15391
Gene Symbols
Cd19
Immunogen
KLH conjugated synthetic phosphopeptide derived from human CD19 around the phosphorylation site of Tyr531 [DS (p-Y)EN].
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CD19 is a member of the immunoglobulin superfamily and has two Ig like domains
- The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains
- CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage
- Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen
- The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias
- Lymphocytes proliferate and differentiate in response to various concentrations of different antigens
- The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors
- CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation
- Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge
- Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.