Phospho-IRAK1 (Thr209) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5210-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5210 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-IRAK1 (Thr209)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Irak1
Gene Alias
AA408924; Il1rak; interleukin 1 receptor associated kinase 1; Interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; Pelle-like protein kinase; Plpk; RGD1563841
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3654
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
P51617
Gene Symbols
Irak1
Immunogen
KLH conjugated synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr209 [RG (p-T)HN].
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens
- IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways
- It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation
- IRAK′s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation
- Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation
- IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus
- This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.