Phospho-IKK alpha/beta (Ser176, Ser180) Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-5241-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-5241 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
Phospho-IKK alpha/beta (Ser176, Ser180)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ikbkb
Gene Alias
AI132552; AI256658; AIM-1; BOS_23346; BOS_23881; CHUK; Chuk1; Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; Fbx24; Fbxo24; I kappa B kinase 1; i kappa-B kinase alpha; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase 2; IkappaB kinase alpha; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkB kinase alpha subunit; IKBKA; Ikbkb; IKK alpha; IKK[b]; IKK1; IKK2; IKK-2; IKKA; IKK-A; IKK-a kinase; IKK-alpha; IKKB; IKK-B; IKKbeta; IKK-beta; IMD15; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; TCF16; TCF-16; TCF17; Transcription factor 16
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1147, 3551
Content And Storage
-20°C
Form
Liquid
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
O14920, O15111
Gene Symbols
CHUK, Ikbkb
Immunogen
KLH conjugated synthetic phosphopeptide derived from human IKK alpha/beta around the phosphorylation site of Ser176/Ser180.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans
- Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins
- This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus
- Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.