UBE2W Rabbit anti-Human, Polyclonal, Bioss
Manufacturer: Bioss
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-198-8518-Each-of-1 | In Stock | ₹ 38,381.25 |
50-198-8518 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,381.25
GST (18%): ₹ 6,908.625
Total Price: ₹ 45,289.875
Antigen
UBE2W
Classification
Polyclonal
Conjugate
Unconjugated
Gene
UBE2W
Gene Alias
6130401J04Rik; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; probable ubiquitin-conjugating enzyme E2 W; UBC16; UBC-16; Ube2w; Ubiquitin carrier protein W; ubiquitin conjugating enzyme E2 W (putative); ubiquitin conjugating enzyme E2W (putative); Ubiquitin-conjugating enzyme 16; ubiquitin-conjugating enzyme 2W; Ubiquitin-conjugating enzyme E2 W; ubiquitin-conjugating enzyme E2 W-like; ubiquitin-conjugating enzyme E2W; ubiquitin-conjugating enzyme E2W (putative); Ubiquitin-protein ligase W
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
55284
Content And Storage
-20°C
Form
Liquid
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Accession No.
Q96B02
Gene Symbols
UBE2W
Immunogen
KLH conjugated synthetic peptide derived from human UBE2W.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- UBE2W accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, and catalyzes monoubiquitination
- Further, UBE2W is involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3
- After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway
- UBE2W In vitro catalyzes ′Lys-11′-linked polyubiquitination, and transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.