Pdcd4Rabbit anti-Human, Mouse, Rat, Xenopus laevis, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1888-Each-of-1 | In Stock | ₹ 35,244.00 |
50-199-1888 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,244.00
GST (18%): ₹ 6,343.92
Total Price: ₹ 41,587.92
Antigen
Pdcd4
Classification
Polyclonal
Formulation
0.02M potassium phosphate with 0.01% BSA, 0.15M NaCl, 25% glycerol and 0.01% sodium azide; pH 7.2
Gene Accession No.
Q53EL6, Q61823, Q9JID1
Gene Symbols
PDCD4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, X. laevis
Product Type
Antibody
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Gene
PDCD4
Gene Alias
D19Ucla1; Death up-regulated gene protein; death-upregulated; Dug; H731; Ma3; MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; PDCD4; programmed cell death 4; programmed cell death 4 (neoplastic transformation inhibitor); Programmed cell death protein 4; Protein 197/15a; Protein MA-3; RP11-348N5.4; Tis; Topoisomerase-inhibitor suppressed protein
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
18569, 27250, 64031
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store vial at 2-8°C prior to opening
- May aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- Dilute only prior to use
- RTU Anti-Pdcd4 affinity purified antibody is directed against human Pdcd4 protein
- A BLAST analysis was used to suggest cross-reactivity with Pdcd4 from human, mouse, rat and Xenopus based on 100% homology with the immunizing sequence
- Cross-reactivity with Pdcd4 from other sources has not been determined
- The antibody reacts with Pdcd4 protein that is either phosphorylated or non-phosphorylated at Ser457
- Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation
- During this process, the expression patterns of numerous genes are radically altered
- One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis
- PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate
- It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1
- The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun
- There are two known isoforms of PDCD4.