MBD1 Mouse anti-Human, Clone: 100B272.1, Active Motif™
Manufacturer: Active Motif
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-2660-Each-of-1 | In Stock | ₹ 52,510.00 |
50-199-2660 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,510.00
GST (18%): ₹ 9,451.80
Total Price: ₹ 61,961.80
Antigen
MBD1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide; pH 7.5
Gene Accession No.
Q9UIS9
Gene Symbols
MBD1
Immunogen
This MBD1 antibody was raised against a synthetic peptide corresponding to human MBD1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
100B272.1
Conjugate
Unconjugated
Gene
MBD1
Gene Alias
CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; Methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
Host Species
Mouse
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4152
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA
- It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides
- Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS)
- MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1
- Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.