LSD1 / KDM1A Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™
Manufacturer: Active Motif
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-3945-Each-of-1 | In Stock | ₹ 53,560.20 |
50-199-3945 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,560.20
GST (18%): ₹ 9,640.836
Total Price: ₹ 63,201.036
Antigen
LSD1 / KDM1A
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KDM1A
Gene Alias
1810043O07Rik; 5330429M20; AA408884; amine oxidase (flavin containing) domain 2; Aof2; BHC110; BOS_2431; BOS_26437; BRAF35-HDAC complex protein BHC110; CPRF; D4Ertd478e; EBI; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; F-box-like/WD repeat-containing protein TBL1X; Flavin-containing amine oxidase domain-containing protein 2; KDM1; KDM1A; KIAA0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine demethylase 1A; lysine-specific demethylase 1; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; mKIAA0601; neuroprotective protein 3; RGD1562975; RGD1563868; RP1-184J9.1; SMAP55; TBL1; Tbl1x; transducin (beta)-like 1 X-linked; transducin (beta)-like 1X-linked; transducin beta like 1 X-linked; transducin beta-like 1; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06; zgc:158242
Host Species
Rabbit
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
ChIP Assay, Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Accession No.
O60341, O60907, Q6ZQ88, Q9QXE7
Gene Symbols
KDM1A, TBL1X
Immunogen
This antibody was raised against full-length recombinant human LSD1 / kDM1A protein.
Regulatory Status
RUO
Gene ID (Entrez)
21372, 23028, 6907, 99982
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor
- LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain
- This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase
- It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed
- LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3
- This protein may play a role in the repression of neuronal genes
- Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
- It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes
- Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.