CD162 (PSGL-1) Monoclonal Antibody (FLEG), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-245-882-Each-of-1 | In Stock | ₹ 32,663.00 |
50-245-882 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,663.00
GST (18%): ₹ 5,879.34
Total Price: ₹ 38,542.34
Antigen
CD162 (PSGL-1)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q14242
Gene Symbols
SELPLG
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6404
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
FLEG
Conjugate
PerCP-eFluor 710
Gene
SELPLG
Gene Alias
CD162; CLA; Cutaneous lymphocyte associated antigen; cutaneous lymphocyte-associated associated antigen; leukocyte cell surface adhesion molecule; P-selectin glycoprotein ligand 1; P-selectin glycoprotein ligand 1 propeptide; P-selectin glycoprotein ligand-1; Psgl1; Psgl-1; Selectin P ligand; selectin, platelet (p-selectin) ligand; Selp1; SELPG; Selpl; SELPLG
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This FLEG monoclonal antibody recognizes human CD162, which is also known as P-selectin glyocoprotein ligand-1 (PSGL-1)
- This 120-kDa protein exists as a homodimer on the surface of monocytes, neutrophils, granulocytes, peripheral T cells, some B cells, and a subset of CD34+ hematopoietic progenitor cells (HPCs) in the bone marrow
- CD162 binds CD62P (P-selectin), CD62E (E-selectin), and CD62L (L-selectin) to mediate leukocyte interactions with each other as well as with activated platelets and endothelium
- Thus, CD162 plays a critical role in leukocyte adhesion and rolling
- Furthermore, the binding of CD162 to P-selectin on HPCs has been demonstrated to inhibit hematopoiesis
- Studies have also demonstrated CD162 as the receptor for enterovirus 71
- Applications Reported: This FLEG antibody has been reported for use in flow cytometric analysis
- Applications Tested: This FLEG antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- This can be used at 5 μL (0.06 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- PerCP-eFluor™ 710 can be used in place of PE-Cy5, PE-Cy5.5 or PerCP-Cy5.5
- PerCP-eFluor™ 710 emits at 710 nm and is excited with the blue laser (488 nm)
- CD162 (PSGL-1) is a 120 kDa homodimer protein found on the surface of leukocytes and platelets
- CD162 is known to bind CD62P (P-selectin), CD62L (L-selectin), and to a lower degree CD62E (E-selectin)
- These interactions play a critical role in leukocyte adhesion, rolling and extravasation
- CD162 has been shown to be an important immune marker of T cell exhaustion in chronic viral infections and cancer.