50-578-982
Aiolos Monoclonal Antibody (8B2), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-578-982-Each-of-1 | In Stock | ₹ 41,474.00 |
50-578-982 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,474.00
GST (18%): ₹ 7,465.32
Total Price: ₹ 48,939.32
Antigen
Aiolos
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O08900
Gene Symbols
Ikzf3
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22780
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
8B2
Conjugate
eFluor 660
Gene
Ikzf3
Gene Alias
5830411O07Rik; AIO; AIOLOS; IKAROS family zinc finger 3; IKAROS family zinc finger 3 (Aiolos); ikaros family zinc finger protein 3; Ikzf3; Zfpn1a3; zinc finger DNA binding protein Aiolos; zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); Znfn1a3
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- This 8B2 MAb reacts with mouse Aiolos, a 58-kDa member of the Ikaros family of zinc finger transcription factors
- Expression of Aiolos is restricted to the lymphoid lineage, with B cells exhibiting the highest levels of expression, followed by NK and T cells
- Studies demonstrate that Aiolos forms homodimers or heterodimerizes with Ikaros proteins
- Moreover, Aiolos exhibits tyrosine phosphorylation and nuclear localization in response to IL-2 stimulation in T cells
- Aiolos plays a role in IL-2-mediated anti-apoptosis by controlling Bcl-2 expression
- Finally, Aiolos is involved in B cell development, with upregulation of this transcription factor observed at the pre-BI to pre-BII transition in response to pre-B cell receptor signaling
- This gene encodes a member of the Ikaros family of zinc-finger proteins
- Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development
- This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation
- Both Ikaros and Aiolos can participate in chromatin remodeling
- Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers
- At least six alternative transcripts encoding different isoforms have been described.