Phospho-4EBP1 (Thr36, Thr45) Monoclonal Antibody (V3NTY24), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-910-742-Each | In Stock | ₹ 33,610.85 |
50-910-742 - Each
In Stock
Quantity
1
Base Price: ₹ 33,610.85
GST (18%): ₹ 6,049.953
Total Price: ₹ 39,660.803
Antigen
Phospho-4EBP1 (Thr36, Thr45)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q13541, Q60876
Gene Symbols
EIF4EBP1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13685, 1978
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
V3NTY24
Conjugate
eFluor 660
Gene
EIF4EBP1
Gene Alias
4EBP1; 4E-BP1; AA959816; BP-1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The V3NTY24 MAb recognizes human and mouse eukaryotic translation initiation factor eIF4E-binding protein 1 (4E-BP1) when phosphorylated at threonine 37 and/or threonine 46
- 4E-BP1 is a member of a family of translation repressor proteins that include 4E-BP2 and 4E-BP3
- In its non-phosphorylated form, 4E-BP1 binds to the eIF4E translation initiation factor and represses cap-dependent translation
- Phosphorylation of 4E-BP1 at multiple sites is necessary to disrupt this interaction and de-repress cap-dependent translation
- Studies have identified several kinases that phosphorylate 4E-BP1
- For instance, FRAP/mTOR phosphorylates Thr37 and Thr46, while ATM phosphorylates Ser111
- Phosphorylation of 4E-BP1 at Thr37 and Thr46 is inhibited by the PI3 kinase inhibitors LY294002 and wortmannin
- This gene encodes one member of a family of translation repressor proteins
- The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs
- Interaction of this protein with eIF4E inhibits complex assembly and represses translation
- This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.