CD137 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 500P167GBT1-Each-of-1 | In Stock | ₹ 3,51,105.00 |
500P167GBT1 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 3,51,105.00
GST (18%): ₹ 63,198.90
Total Price: ₹ 4,14,303.90
Antigen
CD137
Classification
Polyclonal
Conjugate
Biotin
Gene
TNFRSF9
Gene Alias
4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
Host Species
Goat
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Target Species
Human
Form
Lyophilized
Applications
ELISA, Western Blot
Concentration
0.1-1.0 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q07011
Gene Symbols
TNFRSF9
Immunogen
E.coli-derived Recombinant Human 4-1BB Receptor
Quantity
2 x 500 μg
Primary or Secondary
Primary
Content And Storage
-20°C
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Description
- AA Sequence of recombinant protein: MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS
- Preparation: Produced from sera of goats immunized with highly pure Recombinant Human 4-1BB Receptor
- Anti-Human 4-1BB Receptor-specific antibody was purified by affinity chromatography and then biotinylated
- Sandwich ELISA: To detect h4-1BB Receptor by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required
- This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human 4-1BB Receptor (500-P167G) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant h4-1BB Receptor
- Western Blot: To detect h4-1BB Receptor by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
- Used in conjunction with compatible secondary reagents the detection limit for Recombinant h4-1BB Receptor is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
- 500-P167GBT-1MG will be provided as 2 x 500 μg CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells
- Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells
- CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development
- Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival
- Soluble forms of CD137 may provide negative control mechanism for some immune responses.