53-575-282
VSIG4 Monoclonal Antibody (NLA14), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: eBioscience
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-575-282-Each-of-1 | In Stock | ₹ 34,532.00 |
53-575-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,532.00
GST (18%): ₹ 6,215.76
Total Price: ₹ 40,747.76
Antigen
VSIG4
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
0
Gene Symbols
VSIG4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
278180
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
NLA14
Conjugate
Alexa Fluor 488
Gene
VSIG4
Gene Alias
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This NLA14 monoclonal antibody recognizes mouse V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig
- VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins
- It contains one complete V-type Ig domain and one truncated C-type Ig domain
- VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages
- It has been shown to bind complement components C3b and iC3b
- This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens
- VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation
- Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion
- Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4
- Peritoneal macrophages in Balb/c mice express significantly higher levels of VSIG4 than such macrophages in C57Bl/6 or Swiss Webster mice
- The NLA14 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized
- This antibody does not block the ligation of VSIG4 to its T cell ligand
- The NLA14 antibody does not cross-react with rat or human VSIG4
- T cell activation by APCs is positively and negatively regulated by members of the B7 family
- VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.