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5349554

MilliporeSigma™ anti-IL-2 Biotin, Clone: JES6-5H4,

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

IL-2

Applications

Flow Cytometry

Conjugate

Biotin

Host Species

Rat

Research Discipline

Inflammation, Immunology

Formulation

Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.

Gene Symbols

Il2, Il-2

Primary or Secondary

Primary

Content And Storage

2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze

Clone

JES6-5H4

Classification

Monoclonal

Form

Purified

Regulatory Status

RUO

Target Species

Mouse

Gene Accession No.

P04351

Immunogen

Proprietary immunogen

Purification Method

Purified by size-exclusion chromatography

Description

  • Specifically detects IL-2 Clone: JES6-5H4 in Mouse samples, and it is validated for Flow Cytometry The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17kDa cytokine that is secreted by activated T cells
  • This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions
  • IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function
  • The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132)
  • IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.