CDw17 Antibody (HO18.3G-6.F5), Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CDw17
Concentration
0.2 mg/mL
Applications
Flow Cytometry, Immunofluorescence
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene ID (Entrez)
8869
Immunogen
B-2 Microglobulin associated proteins from a detergent lysate of human PBL
Primary or Secondary
Primary
Content And Storage
Store at 4C.
Clone
HO18.3G-6.F5
Dilution
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
ST3GAL5
Isotype
IgM
Purification Method
Protein A or G purified
Test Specificity
CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor alpha (TNFalpha)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
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Description
- Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence CDw17 Monoclonal specifically detects CDw17 in Human samples
- It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.