61-988-341
HELIOS Monoclonal Antibody (22F6), PE-eFluor™ 610, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 61-988-341-Each-of-1 | In Stock | ₹ 19,758.00 |
61-988-341 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,758.00
GST (18%): ₹ 3,556.44
Total Price: ₹ 23,314.44
Antigen
HELIOS
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P81183, Q9UKS7
Gene Symbols
IKZF2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22779, 22807, 488510
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
22F6
Conjugate
PE-eFluor 610
Gene
IKZF2
Gene Alias
A730095J18Rik; ANF1A2; Helios; IKAROS family zinc finger 2; IKAROS family zinc finger 2 (Helios); ikaros family zinc finger protein 2; Ikzf2; Zfpn1a2; zinc finger DNA binding protein Helios; zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; Znfn1a2
Host Species
Armenian Hamster
Quantity
25 Tests
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description: This 22F6 monoclonal antibody reacts with human, mouse and canine Helios
- Helios is a zinc-finger transcription factor first identified for its similarity to Ikaros
- It is expressed in hematopoietic stem cells in both the embryo and adult mice
- While the highest expression is found in regulatory T cells, Helios is not expressed in mature B cells, dendritic cells or myeloid cells
- Helios can form a homodimer as well as heterodimerize with other Ikaros family members to regulate transcription
- Eight isoforms of Helios exist, some of which possess a domit-negative function that has also been found to be upregulated in lymphoid maligcies, including T-acute lymphoblastic leukemia
- 22F6 has been reported to cross react with rat Helios
- Applications Reported: This 22F6 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 22F6 antibody has been pre-titrated and tested by intracellular staining and flow cytometric analysis of mouse lymph node cells using the using the Foxp3/Transcription Factor Buffer Set (cat
- 00-5523) and protocol
- Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins)
- This can be used at 5 μL (0.03 μg) per test
- This gene encodes a member of the Ikaros family of zinc-finger proteins
- Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development
- This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development
- Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.