63-989-180
GARP Monoclonal Antibody (YGIC86), Super Bright™ 600, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 63-989-180-Each-of-1 | In Stock | ₹ 15,308.00 |
63-989-180 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,308.00
GST (18%): ₹ 2,755.44
Total Price: ₹ 18,063.44
Antigen
GARP
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
G3XA59
Gene Symbols
LRRC32
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
434215
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
YGIC86
Conjugate
Super Bright 600
Gene
LRRC32
Gene Alias
AI426318; D11S833E; D11S833Eh; D7H11S833E; EG434215; Garp; garpin; Glycoprotein A repetitions predominant; leucine rich repeat containing 32; leucine-rich repeat-containing protein 32; Lrrc32; Transforming growth factor beta activator LRRC32
Host Species
Rat
Quantity
25μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4)
- So far, at least ten members of the Toll family have been identified in humans
- This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor
- Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation
- TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling
- TLR4 is expressed by peripheral blood monocytes
- HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells
- Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC)
- Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors
- Applications Reported: This HTA125 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This HTA125 antibody has been pre-diluted and tested by flow cytometric analysis of cells transfected with human TLR4
- This may be used at 5 μL (0.5 μg) per test
- GARP, also known as leucine rich repeat containing 32, is a type I membrane protein with twenty-two leucine-rich repeats and a short intracytoplasmic region
- GARP was identified based on the analysis of gene expression profiling of Treg and Th cells following TCR stimulation
- Since GARP is expressed in CD4+, CD25+, FoxP3+ cells (Tregs), it may be a candidate for cell surface marker for Treg cells.