CD5 Monoclonal Antibody (UCHT2), Super Bright™ 645, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 64-005-941-Each-of-1 | In Stock | ₹ 16,465.00 |
64-005-941 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,465.00
GST (18%): ₹ 2,963.70
Total Price: ₹ 19,428.70
Antigen
CD5
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P06127
Gene Symbols
Cd5
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
921
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
UCHT2
Conjugate
Super Bright 645
Gene
Cd5
Gene Alias
alanyl (membrane) aminopeptidase; alanyl aminopeptidase; alanyl aminopeptidase, membrane; aminopeptidase M; Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD antigen CD5; CD13; CD28; CD28 antigen (Tp44); CD28 molecule; Cd5; CD5 antigen; CD5 antigen (p56 62); CD5 antigen (p56-62); CD5 antigen p56-62; CD5 molecule; CD5 protein; CD74 antigen, invariant polypeptide of major; cell surface protein; costimulatory molecule B7 receptor CD28; fCD5; GP150; hAPN; LAP1; LEU1; Ly-1; Ly12; Ly-12; LyA; Ly-A; Lymphocyte antigen 1; Lymphocyte antigen CD5; lymphocyte antigen T1/Leu-1; Lyt-1; membrane alanyl aminopeptidase; microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; P150; Pan T cell; PEPN; T1; T-cell costimulatory molecule CD28; T-cell surface glycoprotein CD5; T-cell-specific surface glycoprotein CD28; unnamed protein product
Host Species
Mouse
Quantity
25 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule
- CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha)
- A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha
- CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells
- Applications Reported: This 53-6.7 antibody has been reported for use in flow cytometric analysis and immunohistology staining of frozen tissue sections
- Applications Tested: This 53-6.7 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Super Bright 645 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 645 nm
- We recommend using a 660/20 bandpass filter
- CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein
- CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas
- CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation
- CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes
- In lymph nodes, the main reactivity is observed in T cell areas
- CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells
- Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.