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70-186-9

KMT2D Recombinant Rabbit Monoclonal Antibody (9H13L17), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 70-186-9-Each-of-1 In Stock ₹ 50,908.00

70-186-9 - Each of 1

₹ 50,908.00

In Stock

Quantity

1

Base Price: ₹ 50,908.00

GST (18%): ₹ 9,163.44

Total Price: ₹ 60,071.44

Antigen

KMT2D

Classification

Recombinant Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

O14686

Gene Symbols

KMT2D

Immunogen

Peptides corresponding to Human KMT2D (aa 2-15, 1071-1082)

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

Immunocytochemistry

Clone

9H13L17

Conjugate

Unconjugated

Gene

KMT2D

Gene Alias

AAD10; ALL1-related protein; ALR; CAGL114; Histone-lysine N-methyltransferase 2D; histone-lysine N-methyltransferase MLL2; KABUK1; Kabuki make-up syndrome; Kabuki mental retardation syndrome; KMS; KMT2D; lysine (K)-specific methyltransferase 2D; lysine methyltransferase 2D; lysine N-methyltransferase 2D; MLL2; MLL4; myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; TNRC21; trinucleotide repeat containing 21

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

8085

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Description

  • This antibody is predicted to react with Monkey, Cat, Mouse and Sheep
  • Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
  • The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
  • Then, individual clones are screened to select the best candidates for production
  • The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
  • KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me)
  • H3K4me represents a specific tag for epigenetic transcriptional activation
  • KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription
  • KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation
  • Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.