SATB1 Recombinant Rabbit Monoclonal Antibody (5H18L16), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-316-2-Each-of-1 | In Stock | ₹ 42,720.00 |
70-316-2 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,720.00
GST (18%): ₹ 7,689.60
Total Price: ₹ 50,409.60
Antigen
SATB1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
Q01826
Gene Symbols
Satb1
Immunogen
Protein corresponding to human SAATB1 [aa250-aa375]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ChIP Assay, Immunocytochemistry, Western Blot
Clone
5H18L16
Conjugate
Unconjugated
Gene
Satb1
Gene Alias
2610306G12Rik; AW413156; DNA-binding protein SATB1; SATB homeobox 1; Satb1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); special AT-rich sequence-binding protein 1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6304
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Mouse, Rat, Bovine SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma
- SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions
- It is thought to recognize the sugar-phosphate structure of double-stranded DNA
- SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling
- SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes
- Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery
- Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.