SHP-1 Recombinant Rabbit Monoclonal Antibody (3H20L13), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 70-356-8-Each-of-1 | In Stock | ₹ 44,500.00 |
70-356-8 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,500.00
GST (18%): ₹ 8,010.00
Total Price: ₹ 52,510.00
Antigen
SHP-1
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.4
Gene Accession No.
P29350
Gene Symbols
PTPN6
Immunogen
Protein corresponding to human SHP-1 [aa243-aa541]
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
3H20L13
Conjugate
Unconjugated
Gene
PTPN6
Gene Alias
70Z-SHP, EC 3.1.3.48, hcp, Hcph, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, HPTP1C, me, motheaten, protein tyrosine phosphatase, non-receptor type 6, protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, PTN6, Ptp1C, PTP-1C, Ptph6, PTPN6, PTPTY-42, SH2 phosphatase 1, SHP1, Shp-1, SHP-1L, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5777
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Monkey, Horse, Cat
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells
- The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain
- SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways
- In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth
- Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation
- Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.