CD90 (Thy-1) Monoclonal Antibody (YKIX337.217), PE, eBioscience™, Invitrogen™

Description

• Description: This YKIX337.217 monoclonal antibody reacts with canine CD90, which is also known as Thy-1
• This 25-37 kDa N-glycoylsated cell adhesion molecule is expressed on thymocytes, peripheral T cells, some B cells, monocytes, and granulocytes albeit at a lower level
• CD90 is also expressed on cells in the bone marrow, brain, and kidney, as well as on mesenchymal stem cells
• This monoclonal antibody has been reported to deplete cells in vitro and in vivo
• Applications Reported: This YKIX337.217 antibody has been reported for use in flow cytometric analysis
• Applications Tested: This YKIX337.217 antibody has been pre-titrated and tested by flow cytometric analysis of normal canine peripheral blood cells
• This can be used at 5 μL (0.5 μg) per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
• Filtration: 0.2 μm post-manufacturing filtered
• CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family
• CD90 is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts
• CD90 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain
• CD90 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons
• Structural study of CD90 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to the first biochemical description and characterization of a vertebrate GPI anchor
• Diseases associated with CD90 dysfunction include nasopharyngeal carcinoma and thymoma.