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7090271

CD278 (ICOS) Monoclonal Antibody (ISA-3), APC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD278 (ICOS)

Concentration

5 μL/Test

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Alias

Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115

Gene Symbols

ICOS

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

ICOS

Clone

ISA-3

Applications

Flow Cytometry

Conjugate

APC

Host Species

Mouse

Target Species

Human

Gene Accession No.

Q9Y6W8

Gene ID (Entrez)

29851

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • Description: The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM
  • ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family
  • Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains
  • Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation
  • ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues
  • Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2
  • ISA-3 has the same reactivity pattern and characteristics as F44
  • ISA-3 was generated against the human ICOS antigen
  • C398.4A, anti-mouse ICOS/H4 (catalog No
  • 14-9949-82), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3
  • C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC
  • To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948-82 or 12-9948-42 rather than 11-9948-42
  • Applications Reported: This ISA-3 antibody has been reported for use in flow cytometric analysis
  • ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family
  • It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation
  • ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.