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7090272

CD278 (ICOS) Monoclonal Antibody (C398.4A), APC, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD278 (ICOS)

Concentration

0.2 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115

Gene Symbols

ICOS

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Gene

ICOS

Clone

C398.4A

Applications

Flow Cytometry

Conjugate

APC

Host Species

Armenian Hamster

Target Species

Mouse, Rat, Rhesus Monkey

Gene Accession No.

Q9R1T7, Q9WVS0

Gene ID (Entrez)

54167, 64545, 705788

Isotype

IgG

Purification Method

Affinity chromatography

Product Type

Antibody

Description

  • Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS
  • ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family
  • A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response
  • ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells
  • C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells
  • It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS
  • The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL)
  • Applications Reported: This C398.4A antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This C398.4A antibody has been tested by flow cytometric analysis of Con A-stimulated mouse splenocytes
  • This can be used at less than or equal to 0.125 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • CD278 (ICOS) Monoclonal antibody specifically detects CD278 (ICOS) in Mouse, Rat, Rhesus Monkey samples
  • It is validated for Flow Cytometry.