7092402
CD11b Rat anti-Mouse, PE-CF594, Clone: M1/70, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11b
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Target Species
Mouse
Immunogen
Mouse Splenic Cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
M1/70
Applications
Flow Cytometry
Conjugate
PE-CF594
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG2b κ
Purification Method
Affinity Purified
Description
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Related Products
Description
- The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM)
- CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family
- CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3)
- Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi
- Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes
- Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface
- The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis
- Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.