7092417
CD138 Mouse anti-Human, PE, Clone: MI15, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD138
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
Syndecan; SDC; Syndecan 1; SDC1; SYND1
Clone
MI15
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human U266 and XG-1 Myeloma Cell Lines
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations
- It is also expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes
- Syndecan-1 is a member of the family of transmembrane heparan sulfate proteoglycans
- It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells
- CD138 binds to many extracellular matrix proteins through its heparan sulfate side-chains, like fibronectin, collagen types I, III, and V, tenascin, thrombospondin, and antithrombin III
- It is considered an extracellular matrix receptor that may serve as a co-receptor for fibroblast growth factor and related molecules
- Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis
- This antibody is routinely tested by flow cytometric analysis
- Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.