7092434
CD16 Mouse anti-Human, APC-H7, Clone: 3G8, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD16
Applications
Flow Cytometry
Conjugate
APC-H7
Regulatory Status
RUO
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Immunogen
Human polymorphonuclear leukocytes
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
3G8
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Immunology
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
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Description
- The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (Fc γRIII), a human NK cell-associated antigen
- CD16 is expressed on NK cells as well as macrophages and granulocytes
- Reports indicate that CD16 plays a role in signal transduction and NK cell activation
- The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes
- The 3G8 antibody is reported (Vossebeld et al ., 1997) to increase intracellular calcium levels in human neutrophils by interacting with both Fc γRIIa and Fc γRIIIb molecules
- This antibody has also been reported to induce homotypic neutrophil aggregation
- This clone also cross-reacts with a subset of peripheral blood lymphocytes and monocytes, but not granulocytes, of baboon and both rhesus and cynomologus macaque monkeys
- Multi-color analysis reveals that the distribution on lymphocytes is similar to that found in human studies with the majority of CD16-positive lymphocytes being both CD3 and CD20 negative.