7092439
CD161 Mouse anti-Human, FITC, Clone: DX12, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD161
Applications
Flow Cytometry
Conjugate
FITC
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Clone
DX12
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Immunology
Immunogen
Human NKR-P1A Transfected Mouse Fibroblasts
Primary or Secondary
Primary
Related Products
Description
- The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A)
- CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene
- CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B)
- CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein
- CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells
- Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells
- Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets
- The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones.