7092496
CD25 Mouse anti-Human, PE-Cy7, Clone: M-A251, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD25
Applications
Flow Cytometry
Conjugate
PE-Cyanine7
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
M-A251
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
IL-2R; IL2RA; IL-2Rα; TCGFR; TAC antigen; p55
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Description
- The M-A251 monoclonal antibody specifically binds to the 55 kDa type I transmembrane glycoprotein known as the low-affinity interleukin-2 receptor alpha chain subunit (IL-2Rα)
- CD25 is expressed on regulatory T cells and on activated lymphocytes (T and B) and monocytes
- It associates with the IL-2Rβ/CD122 and the IL-2Rγ/CD132 receptor chains to form the high-affinity IL-2R complex
- CD25 expression on T and B lymphocytes is upregulated by antigenic or mitogenic stimulation
- Soluble CD25/IL-2Rα is produced as a consequence of lymphocyte stimulation and is found in biological fluids following inflammatory responses.