7092515
CD28 Mouse anti-Human, FITC, Clone: CD28.2, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD28
Applications
Flow Cytometry
Conjugate
FITC
Regulatory Status
RUO
Target Species
Human
Immunogen
Human CD28 Transfected Cell Line
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
CD28.2
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Immunology
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
CD28 antigen; T44; Tp44; TP44
Related Products
Description
- The CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells
- CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in T cell-B cell interactions
- It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from those stimulated by the TCR complex
- Additionally, it has been reported that CD28 antibody clones vary in their ability to stimulate T cells to produce IL-2 and increase intracellular Ca2+ concentration
- This finding suggests the existence of functionally distinct subregions on the CD28 molecule
- CD28.2 has been demonstrated to bind to the same molecule as clone L293, another CD28 mAb, and has been reported to induce Ca2+ influx in Jurkat T cells.