7092539
CD34 Mouse anti-Human, APC, Clone: 581, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD34
Applications
Flow Cytometry
Conjugate
APC
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
581
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
gp105-120; My10; Hematopoietic progenitor cell antigen CD34
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Description
- The 581 monoclonal antibody specifically binds to CD34, a sialomucin-like type I transmembrane glycoprotein
- This single-chain, 105-120 kDa, heavily O-glycosylated protein is expressed on hematopoietic progenitor cells, vascular endothelium, bone marrow stromal cells and embryonic fibroblasts
- The cytoplasmic region of the CD34 antigen is a target for phosphorylation by activated protein kinase C suggesting CD34 may play a role in signal transduction
- CD34 may also play a role as an adhesion molecule since it binds to CD62E and CD62L
- Clone 581 binds to the class III CD34 epitope, it is resistant to neuraminidase, chymopapain and glycoprotease
- The 581 antibody blocks reactivity of another anti-CD34 monoclonal antibody, 8G12.