7092586
CD45 Mouse anti-Human, APC-Cy7, Clone: 2D1, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD45
Applications
Flow Cytometry
Conjugate
APC-Cyanine7
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
2D1
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
PTPRC; CD45R; LCA; L-CA; Leukocyte Common Antigen; B220; T200; GP180; LY5
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Description
- The 2D1 monoclonal antibody recognizes an epitope on all forms of CD45, a tyrosine phosphatase
- CD45 is a type I transmembrane glycoprotein that belongs to the Protein Tyrosine Phosphatase (PTP) family
- There are several isoforms of CD45 with molecular weights ranging from 180 to 220 kDa
- CD45 is expressed on all nucleated cells of hematopoietic origin and is also known as the Leukocyte Common Antigen (LCA)
- CD45 is most highly expressed on lymphocytes and multiple CD45 isoforms can be coexpressed on individual leucocytes
- CD45 plays an important role in regulating leucocyte functions by modifying other signaling molecules.