7092720
CXCR5 Rat anti-Mouse, PE, Clone: 2G8, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CXCR5
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Target Species
Mouse
Immunogen
Mouse CXCR5
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
2G8
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Isotype
IgG2a κ
Purification Method
Affinity Purified
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Description
- The 2G8 monoclonal antibody specifically binds to the mouse CXC chemokine receptor, CXCR5
- CXCR5 is also known as CD185, BLR1, NLR and MDR15
- CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1
- The expression of CXCR5 has been detected in spleen, lymph nodes, tonsils, brain, bone marrow, T cells, B cells, cerebrum, cerebellum, hippcampus and pituitary
- In mouse spleen, CXCR5 was strictly expressed by mature B cells and a small subset of T lymphocytes
- CXCR5 plays a role in directing the migration of B and T cells to B cell follicles with the spleen and certain other lymphoid tissues
- The immunogen used to generate 2G8 hybridoma was a recombinant protein containing N-terminal amino acids of mouse CXCR5 (GST-NmBLR1).