7092785
Nanog Mouse anti-Human, PE, Clone: N31-355, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Nanog
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Clone
N31-355
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Nanog Recombinant Protein
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Description The N31-355 monoclonal antibody reacts with human Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells
- Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone Morphogenic Protein)
- When Nanog expression is down-regulated, cell differentiation can proceed
- Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53
- Nanog is one of the factors that can contribute to reprogramming of differentiated cells to an induced pluripotent stem cell state.