Home Products Antibodies Primary Antibodies 71 069 5
71-069-5

Huntingtin Recombinant Polyclonal Antibody (3HCLC), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 71-069-5-Each-of-1 In Stock ₹ 44,099.50

71-069-5 - Each of 1

₹ 44,099.50

In Stock

Quantity

1

Base Price: ₹ 44,099.50

GST (18%): ₹ 7,937.91

Total Price: ₹ 52,037.41

Antigen

Huntingtin

Classification

Recombinant Polyclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P42858

Gene Symbols

Htt

Immunogen

Peptides corresponding to Human HTT (aa 82-99, 584-601, 650-666)

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

Immunocytochemistry

Clone

3HCLC

Conjugate

Unconjugated

Gene

Htt

Gene Alias

AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

3064

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Description

  • This antibody is predicted to react with Monkey, Mouse and Bovine
  • Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
  • They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
  • While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
  • The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
  • Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons
  • This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
  • HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons
  • The huntingtin gene is widely expressed and is required for normal development
  • It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues
  • The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed
  • The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.