Kappa Light Chain Antibody (KLC264), Novus Biologicals™

Kappa Light Chain

Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml

Monoclonal

Purified

RUO

Human

P01601

3514

Recombinant human Ig kappa chain

Primary

Store at 4C.

22.5 kDa

KLC264

Western Blot, Flow Cytometry, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)

Unconjugated

Mouse

Adaptive Immunity, Immunology

PBS with 0.05% BSA. with 0.05% Sodium Azide

HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809

IGKC

IgG1 κ

Protein A purified

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.