Cadherin-16 Antibody (SPM594) - Azide and BSA Free, Novus Biologicals™

Cadherin-16

1.0 mg/mL

Flow Cytometry, Immunohistochemistry (Paraffin), CyTOF

Unconjugated

Mouse

Human, Mouse, Rat, Canine, Rabbit

cadherin 16, KSP-cadherin, cadherin-16, Kidney-specific cadherin, KSP-cadherin

CDH16

IgG1 κ

Protein A or G purified

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

SPM594

Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, CyTOF-ready

Monoclonal

Purified

RUO

PBS with No Preservative

1014

Recombinant human CDH16 protein

Primary

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

130 kDa