TYRP1 Mouse anti-Human, Mouse, Clone-TYRP1/807, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TYRP1
Concentration
1 mg/mL
Applications
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
Conjugate
Unconjugated
Regulatory Status
RUO
Formulation
PBS with No Preservative
Gene ID (Entrez)
7306
Immunogen
Recombinant full-length human TYRP1 protein
Primary or Secondary
Primary
Content And Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Molecular Weight of Antigen
75 kDa
Clone
TYRP1/807
Dilution
Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 3 - 6 ug/ml, CyTOF-ready
Classification
Monoclonal
Host Species
Mouse
Target Species
Human, Mouse
Gene Alias
b-PROTEIN, CAS25,6-dihydroxyindole-2-carboxylic acid oxidase, Catalase B, CATB, EC 1.14.18, EC 1.14.18.-, EC 1.14.18.1, Glycoprotein 75, GP75DHICA oxidase, Melanoma antigen gp75, TRP-1, TRPTYRP, tyrosinase-related protein 1TRP1, TYRRP
Gene Symbols
TYRP1
Isotype
IgG2a κ
Purification Method
Protein A or G purified
Test Specificity
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Related Products
Description
- TYRP1 Monoclonal specifically detects TYRP1 in Human, Mouse samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.