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7144563

TORC3 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

TORC3

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

TBS with 0.1% BSA and 0.09% sodium azide

Gene Alias

CREB-regulated transcription coactivator 3; TORC-3; transducer of CREB protein 3; transducer of regulated CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; transducer of regulated cAMP response element-binding protein 3

Gene Symbols

CRTC3

Isotype

IgG

Purification Method

Antigen affinity chromatography

Product Type

Antibody

Applications

Immunohistochemistry

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human

Gene Accession No.

Q6UUV7

Gene ID (Entrez)

64784

Immunogen

Between 569 and 619

Primary or Secondary

Primary

Content And Storage

4° C

Gene

CRTC3

Description

  • The recommended shelf life for this product is 1 year from date of receipt
  • Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Chinese ha Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites
  • Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation
  • Enhances the interaction of CREB1 with TAF4
  • Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR
  • Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells
  • Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predomitly expressed in B and T lymphocytes
  • Highest levels in lung
  • Also expressed in brain, colon, heart, kidney, ovary, and prostate
  • Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.