SPAK Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, Chimpanzee and Northern white-cheeked gibbon Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis
• PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus
• PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region
• The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein
• PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death
• PDCD5 may play a dual role in the Tip60 pathway
• It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis
• The nucleotide polymorphisms in the 5'-upstream region ofPDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.