CD89 Monoclonal Antibody (MIP8a), PE, Invitrogen™

Description

• This antibody recognizes the human CD89 cell surface antigen, a 50-75 kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R)
• CD89 is expressed by peripheral blood monocytes and neutrophils
• MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes
• Reconstitute with 1 mL distilled water
• This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA
• The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens
• It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators
• Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.