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7162580

BRCC3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

BRCC3

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Gene Accession No.

P46736

Gene ID (Entrez)

79184

Isotype

IgG

Content And Storage

-20°C or -80°C if preferred

Gene

BRCC3

Applications

ELISA, Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human

Gene Alias

6.1A protein, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRCA1/BRCA2-containing complex, subunit 3, BRCA1-A complex subunit BRCC36, Brcc3, BRCC36, BRISC complex subunit BRCC36, C6.1A, CXorf53, lys-63-specific deubiquitinase BRCC36, RP11-143H17.2

Gene Symbols

BRCC3

Primary or Secondary

Primary

Product Type

Antibody

Description

  • Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity
  • Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage
  • Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors
  • At least two isoforms of BRCC36 are known to exist.