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7188982

RYBP Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

RYBP

Applications

Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human, Mouse

Gene Accession No.

Q8CCI5, Q8N488

Gene ID (Entrez)

23429, 56353

Immunogen

This antibody was raised against a peptide within the C-terminal region of human RYBP.

Primary or Secondary

Primary

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Gene

Rybp

Concentration

Lot-Specific

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Alias

2410018J24Rik; AAP1; APAP-1; Apoptin-associating protein 1; Death effector domain-associated factor; DEDAF; DED-associated factor; RING1 and YY1 binding protein; RING1 and YY1-binding protein; ring1 interactor RYBP; RYBP; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1

Gene Symbols

Rybp

Isotype

IgG

Purification Method

Antigen affinity chromatography

Product Type

Antibody

Description

  • RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development
  • PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
  • Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females
  • May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites
  • Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes
  • May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis
  • May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1
  • May bind to DNA
  • May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.