Mili / PiwiL2 Monoclonal Antibody (17.8), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Mili / PiwiL2
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; HILI; Mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; Piwil1l; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141
Gene Symbols
Piwil2
Isotype
IgG1
Purification Method
Protein G
Product Type
Antibody
Clone
17.8
Applications
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Mouse
Gene Accession No.
Q8CDG1
Gene ID (Entrez)
57746
Immunogen
This Mili / PiwiL2 antibody was raised against full-length recombinant mouse MILI / PIWIL2 protein.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Piwil2
Related Products
Description
- The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family)
- The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse
- MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs)
- A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila
- MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.