Transferrin Polyclonal Antibody, Biotin, Rockland™

Description

• Store vial at 4°C prior to restoration
• For extended storage aliquot contents and freeze at -20°C or below
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• Anti-Transferrin Antibody, Biotin Conjugated, is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above
• Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Biotin, anti-Rabbit Serum as well as purified and partially purified Transferrin [Human Serum]
• Cross reactivities against Transferrin from other sources may occur but have not been specifically determined
• Transferrins (Tf) are an approximately 80kDa blood plasma glycoprotein synthesized by the liver
• They are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate
• It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization
• Transferrin is the primary blood iron transport protein and under normal conditions; approximately one-third of total blood transferrin contains bound iron
• Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis.Serum transferrin may also have a further role in stimulating cell proliferation.