C9orf72 Polyclonal Antibody, Rockland™
Chicken Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
C9orf72
Applications
ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry
Conjugate
Unconjugated
Host Species
Chicken
Target Species
Human
Gene Accession No.
Q96LT7
Gene ID (Entrez)
203228
Immunogen
Anti-C9orf72 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-terminal portion of human C9orf72 surrounding aa 425-481 conjugated to Keyhole Limpet Hemocyanin (KLH).
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
C9orf72
Concentration
1.03 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
0.002M sodium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7
Gene Alias
3110043O21Rik; AI840585; ALSFTD; C9orf72; chromosome 9 open reading frame 72; FTDALS; FTDALS1; Guanine nucleotide exchange C9orf72; Guanine nucleotide exchange C9orf72 homolog; protein C9orf72; protein C9orf72 homolog; RIKEN cDNA 3110043O21 gene
Gene Symbols
C9orf72
Primary or Secondary
Primary
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This affinity purified antibody is directed against human C9orf72
- This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and rat
- C9orf72 may play a role in endosomal trafficking and autophagy
- It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases
- C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome
- Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.