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7190668

Plasminogen Polyclonal Antibody, Rockland™

Goat Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Plasminogen

Applications

ELISA, Immunoprecipitation, Western Blot

Conjugate

Unconjugated

Host Species

Goat

Target Species

Human

Gene Accession No.

P00747

Gene ID (Entrez)

5340

Immunogen

Plasminogen [Human Plasma]

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Gene

PLG

Concentration

1 mg/mL

Classification

Polyclonal

Form

Lyophilized

Regulatory Status

RUO

Formulation

0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2

Gene Alias

Ab1-346; Activation peptide; AI649309; Angiostatin; DKFZp779M0222; Pg; plasmin; Plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B; Plasminogen; PLG; RP1-81D8.1

Gene Symbols

PLG

Primary or Secondary

Primary

Product Type

Antibody

Description

  • Store vial at 4°C prior to restoration
  • For extended storage aliquot contents and freeze at -20°C or below
  • Avoid cycles of freezing and thawing
  • Centrifuge product if not completely clear after standing at room temperature
  • This product is stable for several weeks at 4°C as an undiluted liquid
  • Dilute only prior to immediate use
  • Anti-PLASMINOGEN is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above
  • Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Goat Serum as well as purified and partially purified Plasminogen [Human Plasma]
  • Cross reactivity against Plasminogen from other sources is unknown
  • Plasminogen is a plasma protein synthesized mostly in the liver
  • It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa
  • The plasma concentration is usually in the range of 70 - 200 mg/L
  • Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin
  • Activation results from the cleavage and release of the preactivation peptide
  • Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site
  • Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles
  • Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.